Blake Griffin attended Oklahoma Christian High School, and played alongside his brother, Taylor, for their father who was the head coach. The brothers played together for two seasons, winning back-to-back state championships. In his sophomore season, Blake averaged 13.6 points per game. Taylor left Oklahoma Christian to play for the Oklahoma Sooners in college. In his third straight state championship, Blake tallied 22 points, nine rebounds, and six blocks in a win. He topped his sophomore year by raising his averages to 21.7 points, 12.4 rebounds, and 4.9 assists. He was named the Oklahoman player of the Year. 

Before even starting his senior year, Griffin committed to Oklahoma. This didn’t stop him from having a fantastic senior season. He averaged 26.8 points, 15.1 rebounds, 4.9 assists, and 2.9 blocks per game. He recorded a high school career-best 41 points and 28 rebounds in a game against Oklahoma City Southwest. After a fourth straight state title, Blake was named the Player of the Year, Gatorade Oklahoma Player of the Year, and was named a McDonald’s All-American. He was then ranked 13th overall in his recruitment class.

Blake Griffin followed his brother’s footsteps by attending Oklahoma University. Blake went on to become one of, if not the best, players in Oklahoma University history. In his freshman year, Blake averaged 14.7 points and 9.1 rebounds. After missing some time with injuries, Blake still had the opportunity to enter the 2008 NBA Draft as a projected lottery pick. Instead, he decided to return for his sophomore year. Blake came back strong, showing improvement in just his third game of the season. Griffin poured in 25 points while grabbing 21 rebounds against the Davidson Wildcats. In the very next game, Blake added 35 points and 21 rebounds versus Gardner-Webb. This made him the first player in Big 12 history to record at least 20 points and 20 rebounds in back-to-back games. 

Blake Griffin later went on to top those great performances with a 40 point and 20 rebound game against the Texas Tech Red Raiders. This set him as the only player in Big 12 history to record 40 points and 20 rebounds in a game. Blake continued his dominance into the NCAA Tournament, He tallied 33 points and 17 rebounds against Michigan, setting himself as the second player in the 200s with at least 30 points and 15 rebounds in an NCAA Tournament game. The Sooners, however, went on to lose to North Carolina later in the tournament. In his senior year, Griffin averaged 22.7 points, 14.4 rebounds, and 2.3 assists. He then won the John Wooden Award.

After two solid years as an Oklahoma Sooner, Blake Griffin declared for the 2009 NBA Draft. He was selected 1st overall by the Los Angeles Clippers in the 2009 NBA Draft. Griffin ended up suffering a stress fracture in his left knee in the Summer League, delaying his NBA Debut by seven weeks. Unfortunately, after those seven weeks were up, Blake was forced to get surgery causing him to miss the rest of the 2009-10 season.

In his official NBA debut in 2010-11, Blake tallied 20 points and 14 rebounds versus the Portland Trail Blazers. He then went on to produce 27 consecutive double-doubles, a franchise record. Blake set a then career-high 44 points against the New York Knicks on January 17, 2011. He was voted to the 2011 NBA All-Star Game as a reserve player. Following that, he was named the NBA Rookie of the Year.

Griffin played in his first career All-Star Game in 2012. His 20.7 points and 10.9 rebounds per game helped the Los Angeles Clippers reach the playoffs for the first time since 2006. Following a second-round loss to the San Antonio Spurs, Griffin was named to the All-NBA Second Team. The following year, Griffin signed a $95 million, 5-year extension with the Clippers. With his new payday, he went on to average 18 points and 8.3 rebounds per game.

In 2013, Doc Rivers stepped in as the new head coach for the Clippers. In his first season with Rivers coaching, Blake averaged 24.1 points per game. From January 20 to March 26, he scored 20 or more points in 31 straight games, a new franchise record. Blake continued his dominance, and in 2014 he recorded a season-high 45 points against the Phoenix Suns. shortly after, he recorded his first playoff triple-double against the San Antonio Spurs in Game 2 of the first round. His 29 points, 12 rebounds, and 11 assists were not enough to seal the victory, however. 

In 2015, Griffin began to miss extended time. After a 40 point and 12 rebound night on November 25, 2015, against the Utah Jazz, Blake was ruled out indefinitely just one month later. He suffered from a partially torn left quadriceps and then suffered a right-hand injury. He missed a total of 45 games due to injury and suspension. Injuries began to become a constant theme for Blake. However, in 2016 he became the second-fastest player since 1983-84 to reach 8,500 points, 4,000 rebounds, and 1,500 assists. The following year, Griffin missed the majority of the  2017 NBA Playoffs with an injury to the plantar plate in his right big toe that he suffered in a first-round game with the Utah Jazz. 

Even with the injury woes, the Clippers still re-signed Griffin to a 5-year, $173 million deal. Again, Blake was forced to miss extended time with another injury. He was forced to miss two months with an MCL sprain. In his return, he dropped 24 points against the Los Angeles Lakers. Blake went on to have three 30-point games in the 2017-18 season. On January 20, 2018,  Blake was traded to the Detroit Pistons in a deal involving Avery Bradley, Tobias Harris, Boban Marjanovic, and two draft picks. In his Pistons debut, Griffin tallied 24 points, 10 rebounds, and 5 assists. The following year, Griffin started off hot, by scoring a career-high 50 points in an October 23, 2018 matchup with the Philadelphia 76ers. Towards the end of the year, Blake continued to have injury problems. He missed the final four games of the season, as well as the first two games of the playoffs in 2019. After the playoffs, Blake endured another knee surgery.

Still recovering from the surgery, Blake missed the first 10 games of the 2019-20 season. After just18 games in the season, Griffin had another knee surgery, causing him to miss the remainder of the season.