December 1
20:20
NBC
Highmark Stadium
SF Logo  SF BUF Logo  BUF
1-2
All
3-0
1-0
Home
2-0
0-2
Away
1-0
1-2
as Fav
2-0
0-0
as Dog
1-0
1-2
ATS
2-1
1-0
ATS Home
1-1
0-2
ATS Away
1-0
2-1
O/U
2-1
1-0
O/U Home
2-0
1-1
O/U Away
0-1
DateOppResultSpreadO/U
09/22@
Rams logo
LAR
L 24-27-7.5o45.5
09/15@
Vikings logo
MIN
L 17-23-4.0u46.5
09/09vs
Jets logo
NYJ
W 19-32-3.5o43.5
DateOppResultSpreadO/U
09/23vs
Jaguars logo
JAX
W 10-47-5.5o45.5
09/12@
Dolphins logo
MIA
W 31-10+2.5u49.0
09/08vs
Cardinals logo
ARI
W 28-34-6.5o45.5

Buffalo Bills vs San Francisco 49ers Props

A compelling prop bet to consider for the upcoming Bills vs. 49ers matchup is the total number of passing yards by each team. Both teams feature dynamic quarterbacksโ€”Josh Allen for the Bills and Brock Purdy for the 49ersโ€”who are known for airing it out. Evaluating their historical passing performance against similar defensive setups can provide valuable insights on whether to bet on the over or under for total passing yards in the game.

Buffalo Bills vs San Francisco 49ers Same Game Parlay

Same Game Parlay Betting offers a thrilling way to elevate your NFL betting experience. By combining bets like the total points scored, the winning team, and individual player stats from the Bills vs. 49ers matchup, you can create a potentially high-reward parlay. Delving into team histories, injury updates, and player matchups can significantly boost your chances of success.

Buffalo Bills vs San Francisco 49ers Moneyline

Moneyline Betting offers a simple and direct way to wager on NFL games by picking the outright winner without worrying about the point spread. For the upcoming Bills vs. 49ers matchup, focus on recent team performances, injury reports, and historical head-to-head data to make an informed decision. By analyzing these key factors, you can enhance your chances of success in this straightforward betting format.

Buffalo Bills vs San Francisco 49ers Over/Under

Over/Under Betting is a thrilling way to engage with NFL games by predicting the total points scored by both teams. For the upcoming Bills vs. 49ers matchup, focus on each team’s offensive firepower and defensive prowess. Analyze recent scoring trends, injury reports, and weather conditions to make a well-informed decision. This type of bet is perfect for those who relish diving into game dynamics and statistical analysis. Bet smart and enjoy the added excitement!

Buffalo Bills vs San Francisco 49ers Spread

Spread Betting introduces an added thrill to NFL matchups by forecasting the victory margin. This bet requires you to determine if a team will win by more or fewer points than a predetermined spread. By examining team stats, player performances, and recent trends, you can place informed bets. Engaging in Spread Betting shifts the focus from merely choosing a winner to predicting the score gap. This bet type suits those who relish delving into game intricacies and team dynamics. Evaluate elements like offensive firepower, defensive sturdiness, and past encounters to make educated choices. Spread Betting provides a clear-cut method to bet on NFL games by estimating the final score difference. To boost your chances, consider each team’s scoring ability, defensive tactics, and game-day conditions. By researching thoroughly and keeping abreast of team updates, you can make well-informed spread bets.

Stats

In the upcoming NFL showdown between the Buffalo Bills and the San Francisco 49ers, the Bills’ quarterback’s performance will be vital for their success. Historically, the Bills’ quarterback has exhibited remarkable abilities, including precise passing, strong arm strength, and the knack for making plays under pressure. His dynamic playing style will test the 49ers’ defense, compelling them to stay alert and adapt swiftly. The quarterback’s leadership and connection with his receivers will be a significant factor in determining the outcome of the game. Ultimately, the Bills’ success in this matchup will depend on key performances during crucial moments.

Full Roster

Reflecting on their past encounters, the Buffalo Bills appear poised to come out on top in their upcoming game against the San Francisco 49ers. The Bills’ robust offense, steered by a talented quarterback and a versatile group of receivers, has repeatedly posed significant challenges for the 49ers’ defense. Additionally, Buffalo’s defense has shown a consistent ability to stifle San Francisco’s offensive drives in previous matchups, positioning them as the likely favorites.

Player and Team Statistics

Offense
73
Points
112
1,222
Offensive Yards
987
803
Passings Yards
627
1
Interceptions
0
97
Rushing Attempts
88
419
Rushing Yards
360
5
Fumbles
2
Defense
69
Points Against
48
965
Yards Against
860
653
Passing Yards
505
312
Rushing Yards
355
2
Fumbles Recovered
2
2
Interceptions
4
8
Sacks
11
PassingC/ATTYDSTDINTRTG
B.Purdy QB69/9584241109.2
RushingCARYDSAVGTDRTG
J.Mason RB673244.820.0
B.Purdy QB13644.90109.2
D.Samuel Sr. WR10131.310.0
B.Allen QB1-1-1.000.0
ReceivingRECYDSAVGTDRTG
J.Jennings WR1827615.330.0
B.Aiyuk WR1111910.800.0
D.Samuel Sr. WR1316412.600.0
G.Kittle TE1111610.510.0
K.Juszczyk FB66510.800.0
E.Saubert TE46716.800.0
J.Mason RB4205.000.0
R.Bell WR11212.000.0
C.Conley WR144.000.0
DefenseTOTSOLOSACKINTRTG
F.Warner LB2013110.0
D.Campbell Sr. LB157000.0
D.Lenoir CB148000.0
C.Ward CB139000.0
I.Yiadom CB1310000.0
N.Bosa DL96200.0
M.Collins DT75100.0
J.Hargrave DL74100.0
T.Hufanga S74000.0
L.Floyd DE64100.0
G.Odum S55000.0
K.Givens DL31100.0
D.Flannigan-Fowles LB33010.0
J.Elliott DT22000.0
R.Beal Jr. DL21000.0
R.Green CB20000.0
B.Purdy QB1100109.2
C.Conley WR11000.0
E.Saubert TE11000.0
J.Tonges TE11000.0
A.Banks G10000.0
D.Puni G10000.0

INJURY REPORT

NAMEPOSSTATUSINJURYNOTES
Brock Purdy
POS
QB
STATUS
Questionable
INJURY
Back
Notes
Week 4
Deebo Samuel Sr.
POS
WR
STATUS
Questionable
INJURY
Calf
Notes
Week 4
George Kittle
POS
TE
STATUS
Questionable
INJURY
Hamstring
Notes
Week 4
Javon Hargrave
POS
DL
STATUS
Out
INJURY
Triceps
Notes
Hargrave suffered a torn triceps and is expected to miss the remainder of the 2024-25 season.
Dee Winters
POS
LB
STATUS
Questionable
INJURY
Ankle
Notes
Week 4
full roster and injuries
PassingC/ATTYDSTDINTRTG
J.Allen QB54/7263470133.7
M.Trubisky QB1/130079.2
RushingCARYDSAVGTDRTG
J.Cook RB411884.630.0
R.Davis RB19643.410.0
J.Allen QB17855.02133.7
T.Johnson RB6244.000.0
M.Trubisky QB3-3-1.0079.2
C.Samuel WR100.000.0
K.Shakir WR122.000.0
ReceivingRECYDSAVGTDRTG
K.Shakir WR1416812.020.0
D.Kincaid TE88510.610.0
J.Cook RB89712.110.0
K.Coleman WR57515.010.0
C.Samuel WR6406.700.0
T.Johnson RB46115.210.0
M.Hollins WR34113.710.0
M.Valdes-Scantling WR22613.000.0
D.Knox TE23015.000.0
R.Davis RB3144.700.0
DefenseTOTSOLOSACKINTRTG
D.Williams LB2918000.0
C.Lewis DB2115000.0
D.Hamlin S1913010.0
B.Spector LB1610000.0
C.Benford CB1412010.0
T.Bernard LB1312000.0
G.Rousseau DE119300.0
R.Douglas CB117000.0
E.Oliver DT65100.0
A.Epenesa DE64100.0
C.Toohill DE54100.0
V.Miller LB55300.0
A.Johnson DT44000.0
J.Ingram CB43120.0
D.Jones DT30000.0
K.Elam CB32000.0
J.Andreessen LB21000.0
C.Bishop S21000.0
T.Johnson RB11000.0
M.Hollins WR10000.0
J.Solomon DE11100.0
T.Johnson CB10000.0

INJURY REPORT

NAMEPOSSTATUSINJURYNOTES
Terrel Bernard
POS
LB
STATUS
Out
INJURY
Pectoral
Notes
Bernard has been ruled out heading into Week 4 versus the Ravens.
Taron Johnson
POS
CB
STATUS
Out
INJURY
Forearm
Notes
Johnson has been ruled out heading into Week 4 versus the Ravens.
full roster and injuries
Home ยป Buffalo Bills vs San Francisco 49ers Predictions