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San Francisco 49ers vs. Los Angeles Rams MoneyLine 09/22/2024

San Francisco 49ers

1-2

FINAL

24-27

FOX

SoFi Stadium

Los Angeles Rams

1-2

San Francisco 49ers vs. Los Angeles Rams GAME PICK

The San Francisco 49ers take on the Los Angeles Rams September 22nd, 2024 at SoFi Stadium at 4:25 pm

San Francisco 49ers vs. Los Angeles Rams ODDS

• Moneyline: 49ers -300 (FanDuel), Rams +280 (BetMGM)
• Point Spread: 49ers -7.0 (-105 FanDuel), Rams +7.0 (-105 Caesars Casino)
• Total: Over 43.5 (-110 Caesars Casino), Under 44.0 (-115 BetRivers)

BETTING TRENDS

• Record: 49ers: 2-0 Rams: 1-1
• ATS: 49ers: 2-0 Rams: 2-0
• Over/Under: 49ers: 1-1 Rams: 1-1

MATCHUP PREVIEW

The San Francisco 49ers visit the Los Angeles Rams at SoFi Stadium on September 22nd, 2024, at 4:25 PM. The 49ers come in with a 1-1 record, while the Rams are 0-2. Brock Purdy has been efficient for the 49ers, completing 47 of 65 passes for 550 yards, one touchdown, and one interception. Jordan Mason has been a reliable force on the ground, rushing for 247 yards and two touchdowns on 48 carries. The 49ers will miss key players like Christian McCaffrey and Deebo Samuel Sr. due to injuries, but their defense, led by Talanoa Hufanga and Dee Winters, remains strong. On the Rams’ side, Matthew Stafford has thrown for 533 yards with one touchdown and one interception. Kyren Williams has struggled to find running room, averaging just 2.5 yards per carry on 30 attempts. The Rams’ offense takes a hit with Cooper Kupp out due to an ankle injury. The Rams’ defense will need to step up, but injuries to key players like John Johnson III and Jonah Jackson could make this a tall order. Given the 49ers’ balanced attack and defensive prowess, they have the edge in this matchup, despite the injuries. The Rams’ offensive struggles and defensive injuries further tilt the scales in favor of San Francisco.

NFL Computer Pick

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