The San Francisco 49ers take on the Arizona Cardinals January 5th, 2025 at State Farm Stadium at 4:25 pm
Moneyline: 49ers —, Cardinals — Point Spread: 49ers —, Cardinals — Total: Over —, Under —
The San Francisco 49ers travel to State Farm Stadium to take on the Arizona Cardinals on January 5th, 2025. Both teams come into this matchup with a lot at stake as the season winds down. The Cardinals, with a 7-9 record, have shown flashes of brilliance, largely fueled by Kyler Murray’s dynamic playmaking ability. Murray’s dual-threat capabilities are evident, with over 3,600 passing yards and an additional 550 rushing yards this season. His connection with standout rookie Marvin Harrison Jr., who has seven touchdowns, adds another layer to Arizona’s offensive threat. Conversely, the 49ers, at 6-9, have been plagued by a slew of injuries to key players, including Christian McCaffrey and Brandon Aiyuk, which has severely impacted their offensive rhythm. Brock Purdy has been steady under center, but without his primary weapons, the 49ers’ offense has struggled to maintain consistency. Defensively, the 49ers have been stout, but the absence of several defensive starters could tilt the balance in Arizona’s favor. Given the Cardinals’ recent victory against the 49ers earlier in the season and their superior offensive efficiency, they seem poised to capitalize on a depleted San Francisco roster. While the 49ers’ defense has been resilient, the Cardinals’ offensive versatility and home-field advantage make them a compelling pick in this matchup.
Affiliate Disclosure: Lines may receive advertising commissions for visits to a sportsbook or betting site.
All content, materials, programs, services, and software contained on or made available by this site are for entertainment, educational, and informational purposes only. Any use of the foregoing in violation of local, state, federal, provincial, or national law is strictly prohibited. Lines.com does not warrant the legality of any particular gambling activities in any user’s specific location. Laws and regulations change continually worldwide, and it is the visitor’s responsibility to ensure that any gambling actions or behaviors they undertake are legal in their relevant jurisdiction.
NFL Predictions
NFL Picks
No matchups found for the selected week.