San Francisco 49ers vs. Arizona Cardinals MoneyLine 01/05/2025

San Francisco 49ers

6-10

January 5

16:25

FOX

State Farm Stadium

Arizona Cardinals

7-9

San Francisco 49ers vs. Arizona Cardinals GAME PICK

The San Francisco 49ers take on the Arizona Cardinals January 5th, 2025 at State Farm Stadium at 4:25 pm

San Francisco 49ers vs. Arizona Cardinals ODDS

Moneyline: 49ers —, Cardinals — Point Spread: 49ers —, Cardinals — Total: Over —, Under —

BETTING TRENDS

• Record: 49ers: 7-9 Cardinals: 6-9
• ATS: 49ers: 8-7 Cardinals: 6-8
• Over/Under: 49ers: 9-5 Cardinals: 6-9

MATCHUP PREVIEW

The San Francisco 49ers and Arizona Cardinals are set to clash at State Farm Stadium on January 5th, 2025. Despite a season filled with injuries, the 49ers remain a formidable force with key players like Brock Purdy and George Kittle leading the charge. Purdy has been effective with 3,487 passing yards and 17 touchdowns, while Kittle continues to be a reliable target with 967 receiving yards and 8 touchdowns. However, the 49ers face significant challenges with a plethora of injuries to key players, including Christian McCaffrey and Brandon Aiyuk, which could impact their offensive rhythm. On the other hand, the Cardinals, led by Kyler Murray, have shown resilience throughout the season. Murray’s dual-threat ability is evident with over 3,600 passing yards and 550 rushing yards, making him a critical component of Arizona’s offense. The Cardinals’ defense, while not the strongest, has been opportunistic, and the team has a slight edge in offensive efficiency. With fewer injuries compared to the 49ers, the Cardinals are in a better position to capitalize on their opponent’s weakened lineup. Given the current form and injury situation, the Cardinals appear to have the upper hand in this matchup. Their ability to exploit the 49ers’ depleted roster and home-field advantage makes them the more favorable pick.

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