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San Francisco 49ers vs. Buffalo Bills Prop 12/01/2024

December 1
20:20
NBC
Highmark Stadium
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San Francisco 49ers vs. Buffalo Bills GAME PICK

The San Francisco 49ers take on the Buffalo Bills December 1st, 2024 at Highmark Stadium at 8:20 pm

San Francisco 49ers vs. Buffalo Bills ODDS

  • Moneyline: 49ers +265 (FanDuel), Bills -310 (DraftKings)
  • Point Spread: 49ers +7.0 (-105 Caesars Casino), Bills -6.5 (-120 FanDuel)
  • Total: Over 44.5 (-110 Caesars Casino), Under 44.5 (-107 BetRivers)

BETTING TRENDS

  • Record: 49ers: 4-7 Bills: 9-2
  • ATS: 49ers: 6-5 Bills: 7-4
  • Over/Under: 49ers: 7-4 Bills: 5-6

MATCHUP PREVIEW

The San Francisco 49ers will clash with the Buffalo Bills in what promises to be a thrilling encounter. The 49ers, led by their dynamic offense and stout defense, have been a force to reckon with this season. Quarterback Brock Purdy’s precision and Christian McCaffrey’s explosive running game are key components of their offensive arsenal. On the defensive side, Nick Bosa and Fred Warner anchor a unit that excels at applying pressure and forcing turnovers. The Bills, with Josh Allen at the helm, boast a high-powered offense capable of lighting up the scoreboard. Allen’s dual-threat capability, combined with Stefon Diggs’ elite receiving skills, makes them a formidable opponent. However, the Bills’ defense has shown vulnerabilities, particularly against the run, which the 49ers are well-equipped to exploit. Given the 49ers’ balanced attack and defensive prowess, they have the edge in this matchup.

NFL Computer Pick
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Lines.com 11/24 12:36

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